Novel skeleton terpenes from Celastrus hypoleucus with anti-tumor activities

Celahypodiol 1, an unusual 17-membered carbon diterpenoid with a novel skeleton, and a new triterpenoid 12-oleanene-3β,6α-diol 2, together with four known compounds furreginol 3, suigol 4, 20(30)-lupene-3β, 29-diol 5, and 20(29)-lupene-1β,3β-diol 6, were isolated from the stalks of Celastrus hypoleucus (Oliv.) Warb. Their structures were established by means of spectroscopic analysis, including 2D NMR. The new compounds exhibited anti-tumor activities against a panel of human tumor cell lines.

Graphical abstractCelahypodiol 1, an unusual 17-membered carbon diterpenoid with a novel skeleton, and a new triterpenoid 12-oleanene-3β,6α-diol 2, together with four known compounds, were isolated from the stalks of Celastrus hypoleucus (Oliv.) Warb. Their structures were established by means of spectroscopic analysis, including 2D NMR. The new compounds exhibited anti-tumor activities against a panel of human tumor cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide