Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374982 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Crystallographic studies of a range of 3-substituted anilinopyrimidine inhibitors of EphB4 have highlighted two alternative C-2 aniline conformations and this discovery has been exploited in the design of a highly potent series of 3,5-disubstituted anilinopyrimidines. The observed range of cellular activities has been rationalised on the basis of physicochemical and structural characteristics.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Catherine Bardelle, Tanya Coleman, Darren Cross, Sara Davenport, Jason G. Kettle, Eun Jung Ko, Andrew G. Leach, Andrew Mortlock, Jon Read, Nicola J. Roberts, Peter Robins, Emma J. Williams,