Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374988 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Acetogenins of the Annonaceae are strong inhibitors of mitochondrial complex I but discrepancies in the structure/activity relationships pled the search for other targets within the whole cell proteome. Combining hemisynthetic work, Cu-catalyzed Huisgen cycloaddition and proteomic techniques we have identified new putative protein targets of squamocin ruling out the previously accepted ‘complex I dogma’. These results give new insights into the mechanism of action of these potent neurotoxic molecules.
Graphical abstractCombining hemisynthetic work, Cu-catalyzed Huisgen cycloaddition and proteomic techniques, we have identified new putative protein targets of squamocin ruling out the previously accepted ‘complex I dogma’ in the annonaceous acetogenin series.Figure optionsDownload full-size imageDownload as PowerPoint slide