| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374997 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A small family of S-DABO cytosine analogs (S-DABOCs) has been synthesized and biologically evaluated as HIV-1 inhibitor both on wild type and drug-resistant mutants. An interesting compound (5d) has been identified which showed a predicted pharmacokinetic profile similar to that of anti-HIV drugs on the market. Molecular modeling studies have been finally performed in order to rationalize the results.
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Authors
Marco Radi, Lucilla Angeli, Luigi Franchi, Lorenzo Contemori, Giovanni Maga, Alberta Samuele, Samantha Zanoli, Mercedes Armand-Ugon, Emmanuel Gonzalez, Anuska Llano, Jose A. Esté, Maurizio Botta,