| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375002 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
The synthesis and biological activity of a new series of 2-aryloxymethylmorpholine histamine H3 antagonists is described. The new compounds are high affinity histamine H3 ligands that penetrate the CNS and occupy the histamine H3 receptor in rat brain.
Graphical abstract2-Aryloxymethylmorpholines are potent histamine H3 antagonists.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michael A. Letavic, John M. Keith, Kiev S. Ly, Pascal Bonaventure, Mark A. Feinstein, Brian Lord, Kirsten L. Miller, S. Timothy Motley, Diane Nepomuceno, Steven W. Sutton, Nicholas I. Carruthers,