Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375019 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
In this Letter we report the synthesis and in vitro studies of cleavable polymer–drug conjugates derived from dendritic polyglycerol and maleimide-bearing prodrugs of doxorubicin and methotrexate that are cleaved by cathepsin B. Cleavage properties and cytotoxicity of the new conjugates are presented.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Marcelo Calderón, Ralph Graeser, Felix Kratz, Rainer Haag,