| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375034 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
We have shown that manassantin A downregulated the HIF-1α expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin A.
Graphical abstractHIF-1 inhibition by manassantin A (1) and analogues with modified tetrahydrofuran configurations (11 and 13) is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Amanda C. Kasper, Eui Jung Moon, Xiangqian Hu, Yongho Park, Ceshea M. Wooten, Hyoungsu Kim, Weitao Yang, Mark W. Dewhirst, Jiyong Hong,