Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375041 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
The proximicins A-C (1-3) are novel naturally occurring γ-peptides with a hitherto unknown 2,4-disubstituted furan amino acid as a core structure. They show a moderate cytotoxic activity and induce upregulation of cell cycle regulating proteins (p53 and p21) and lead to cell cycle arrest in G0/G1-phase. Hybrid molecules combining structural motifs of the proximicins and of netropsin (4), a structurally related natural product, seem to have similar effects. Herein we describe the synthesis of a netropsin-proximicin-hybrid library and its evaluation regarding cytotoxicity and minor groove binding activity.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Falko E. Wolter, Lise Molinari, Elke R. Socher, Kathrin Schneider, Graeme Nicholson, Winfried Beil, Oliver Seitz, Roderich D. Süssmuth,