| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375047 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Pochoximes are potent inhibitors of heat shock protein 90 (HSP90) based on the radicicol pharmacophores. Herein we present a pharmacokinetics and pharmacodynamics evaluation of this compound series as well as a phosphate prodrug strategy to facilitate formulation and improve oral bioavailability.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cuihua Wang, Sofia Barluenga, Girish K. Koripelly, Jean-Gonzague Fontaine, Ruihong Chen, Jin-Chen Yu, Xiaodong Shen, John C. Chabala, James V. Heck, Allan Rubenstein, Nicolas Winssinger,