| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375055 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A rapid array-based protocol is presented by which a modest affinity protein-binding small molecule can be appended to a library of peptoids via click chemistry. The array can then be screened for improved ligands that exhibit a higher affinity for the protein target.
Graphical abstractA rapid array-based protocol is presented by which a modest affinity protein-binding small molecule can be appended to a library of peptoids via click chemistry. The array can then be screened for improved ligands that exhibit a higher affinity for the protein target.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hyun-Suk Lim, M. Muralidhar Reddy, Xiangshu Xiao, Johnnie Wilson, Rosemary Wilson, Steven Connell, Thomas Kodadek,