| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375060 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
The aldol reaction of the endogeneous compounds acetone and methylglyoxal has been studied using organocatalysis in relation to biologically relevant non-enzymatic reactions. Under preparative conditions, 3-hydroxy-2,5-hexadione, known as Henze’s ketol, is formed in high yield and with enantioselectivities up to 88% ee. Furthermore, Henze’s ketol is also formed under simulated physiological conditions at micromolar scale, indicating that this reaction might take place in living organisms.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David G. Alberg, Thomas B. Poulsen, Søren Bertelsen, Kasper L. Christensen, Rune D. Birkler, Mogens Johannsen, Karl Anker Jørgensen,