Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375063 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Au(I) catalyzed 1,2,3-triazole addition to non-activated alkyne was reported. A large group of substituted NH-1,2,3-triazoles were suitable for this transformation along with both internal and terminal alkynes. The N-1 and N-2 vinyl substituted 1,2,3-triazoles were prepared in up to 98% yield with as low as 0.2% catalyst loading, thereby providing a new protocol for the synthesis of potentially biological-active vinyl-triazole building blocks.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Haifeng Duan, Wuming Yan, Sujata Sengupta, Xiaodong Shi,