| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375064 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
The human telomeric G-quadruplex structure is a promising target for the design of cancer drugs. The selectivity of G-quadruplex ligands with respect to duplex genomic DNA is of especial importance. The high selectivity of polyamine conjugated perylene derivatives appears to be regulated by side-chain charge density, as indicated by data from a FRET melting assay and induced CD spectroscopy.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Emanuela Micheli, Caterina Maria Lombardo, Danilo D’Ambrosio, Marco Franceschin, Stephen Neidle, Maria Savino,