| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375072 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Reaction progress kinetic analysis of the proline-mediated intermolecular aldol reaction shows that the rate depends on the concentrations of both the donor ketone1 and the electrophilic aldehyde 2, implying that enamine formation cannot be rate-determining. The observed kinetics and deuterium isotope effects are consistent with formation of the product iminium species as the rate-determining step.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Natalia Zotova, Linda J. Broadbelt, Alan Armstrong, Donna G. Blackmond,