| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375078 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Optically active lactones are important synthons in perfume and aroma manufacturing. Therefore, developments of efficient asymmetric syntheses are desired. Organocatalytic asymmetric α-hydroxymethylations of cyclopentanone with aqueous formaldehyde have been developed, to furnish the corresponding α-(hydroxymethyl)cyclopentanone with high enantioselectivity. Further chemical transformation of α-(hydroxymethyl)cyclopentanone gave the key intermediate for jasmine lactone, which is widely found in fruits and flowers.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nobuyuki Mase, Azusa Inoue, Masaki Nishio, Kunihiko Takabe,