| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375083 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
The first asymmetric synthesis of (S)- and (R)-5-hydroxythalidomides (2), one of thalidomide's major metabolites, was achieved. Configurational stability and stereochemical biological evaluation of (S)- and (R)-1 and 2 were investigated.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takeshi Yamamoto, Norio Shibata, Daisuke Sukeguchi, Masayuki Takashima, Shuichi Nakamura, Takeshi Toru, Nozomu Matsunaga, Hideaki Hara, Motohiro Tanaka, Tohru Obata, Takuma Sasaki,