| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375091 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Three new homoisoflavonoids (1−3) were isolated from the roots of Ophiopogon japonicus (Liliaceae). The structures of new metabolites were determined on the basis of spectroscopic analyses including 2D NMR. The anti-inflammatory activities of new compounds (1−3) were investigated by their effects on the release of the inflammatory chemokine eotaxin, stimulated by IL-4 and the combination of IL-4 and TNF-α in BEAS-2B cells, which mimics the in vivo conditions in bronchial allergic asthma.
Graphical abstractThree new homoisoflavonoids (1−3) were isolated from the roots of Ophiopogon japonicus (Liliaceae) and investigated by their effects on the release of the inflammatory chemokine eotaxin, stimulated by IL-4 and the combination of IL-4 and TNF-α in BEAS-2B cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
