Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375092 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Eight hydroxyl-substituted Schiff bases with the different number and position of hydroxyl group on the two asymmetric aromatic rings (A and B rings) were prepared by the reaction between the corresponding aromatic aldehyde and aniline. Their antioxidant effects against the stable galvinoxyl radical (GO) in ethyl acetate and methanol, and 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH)-induced DNA strand breakage, and their antiproliferative effects on human hepatoma HepG2 cells, were investigated. Structure–activity relationship analysis demonstrates that o-dihydroxyl groups on the aromatic A ring and 4-hydroxyl group attached to the aromatic B ring contribute critically to the antioxidant and antiproliferative activities.
Graphical abstractEight hydroxyl-substituted Schiff bases were synthesized and bio-evaluated for their antioxidant and antiproliferative activities. Structure–activity relationship analysis indicates that o-diphenolic groups and 4-hydroxyl group attached to the aromatic B ring contribute critically to the activities.Figure optionsDownload full-size imageDownload as PowerPoint slide