Synthesis and SOD activity of manganese complexes of substituted pyridino pentaaza macrocycles that contain axial auxiliary

New manganese(II) complexes of substituted pyridino pentaaza macrocyclic ligands were prepared. The amino-, carboxy-, or other functional groups were placed in the vicinity of the axial position of the metal complex. Their SOD-like activity was determined by cytochrome c assay and compared with one another. The activities of pyridine analogs (12a–b and 13) and m-substituted analogs (12c and 12j) were similar and significantly better than that of the standard compound M-40403. The most potent compound was an o-aminobenzoyl derivative 12i, while the o-carboxybenzoyl analog 12d was the lowest active compound.

Graphical abstractThe synthesis and SOD-like activity of new manganese(II) complex of substituted pyridino pentaaza macrocyclic ligands are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide