| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375098 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A series of alkenyl indazoles were synthesized and evaluated in Aurora kinase enzyme assays. Several promising leads were optimized for selectivity towards Aurora B. Excellent binding affinity and good selectivity were achieved with optimized compounds in isolated Aurora subfamily assays.
Graphical abstractA series of alkenyl indazole derivatives were prepared and evaluated as selective Aurora inhibitors.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stéphanie Blanchard, Anthony D. William, Angeline C.-H. Lee, Anders Poulsen, Ee Ling Teo, Weiping Deng, Noah Tu, Evelyn Tan, Kay Lin Goh, Wai Chung Ong, Chee Pang Ng, Kee Chuan Goh, Zahid Bonday, Eric T. Sun,