Antimicrobial selaginellin derivatives from Selaginella pulvinata

Six selaginellin derivatives, including three new analogues selaginellins D–F (1–3), were isolated from the EtOAc extract of the whole plant of Selaginella pulvinata (Hook. et Grev.) Maxim. Their structures were determined on the basis of extensive physical and chemical evidence. Compounds 1 and 4 demonstrated antifungal activities against Candida albicans; compounds 4–6 exhibited significant antibacterial activity against Staphylococcus aureus.

Graphical abstractSelaginellin derivatives from Selaginella pulvinata with good antimicrobial activity.Figure optionsDownload full-size imageDownload as PowerPoint slide