Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375102 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 μM. The structure–activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one.
Graphical abstractThe minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC) and antibiofilm concentration assay of 1x were 6.25 μM, 25 μM and 6.25 μM against Staphylococcus epidermidis, respectively.Figure optionsDownload full-size imageDownload as PowerPoint slide