| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375105 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A-ring modifications on the triazafluorenone core structure were investigated. Five membered heterocycles such as pyrazoles and isothiazoles are not tolerated. It has been found that the pyrimidine nucleus was very well tolerated on the left hand side. Amino pyrimidine compounds 24 and 27 showed acceptable PK profile with significant brain penetration. Compound 9 served as a versatile intermediate for a number of chemical transformations.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
T.K. Sasikumar, Li Qiang, Duane A. Burnett, William J. Greenlee, Cheng Li, Mariagrazia Grilli, Rosalia Bertorelli, Gianluca Lozza, Angelo Reggiani,