| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375113 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Novel N-aryltriazole nucleosides were synthesized via Cu-mediated C–N cross-coupling reaction starting with 3-aminotriazole ribonucleoside and various boronic acids. Two of them exhibited potent apoptosis-related antiproliferative activity against the drug-resistant pancreatic cancer cell line MiaPaCa-2, with an increased potency compared to gemcitabine, the reference treatment for pancreatic cancer. A preliminary SAR study suggests that the appended N-aryl moiety and the substituent at its para-position, as well as the ribose sugar component, contribute considerably to the observed antiproliferative activity.
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Related Topics
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Authors
Yang Liu, Yi Xia, Yuting Fan, Alain Maggiani, Palma Rocchi, Fanqi Qu, Juan L. Iovanna, Ling Peng,