Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375125 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Novel Aurora inhibitors were identified truncating clinical candidate GSK1070916. Many of these truncated compounds retained potent activity against Aurora B with good antiproliferative activity. Mechanistic studies suggested that these compounds, depending on the substitution pattern, may or may not exert their antiproliferative effects via inhibition of Aurora B. The SAR results from this investigation will be presented with an emphasis on the impact structural changes have on the cellular phenotype.
Graphical abstractThe SAR results from this investigation will be presented with an emphasis on the impact structural changes have on the cellular phenotype.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jesus R. Medina, Seth W. Grant, Jeffrey M. Axten, William H. Miller, Carla A. Donatelli, Mary Ann Hardwicke, Catherine A. Oleykowski, Qiaoyin Liao, Ramona Plant, Hong Xiang,