| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375131 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the human GPR119 receptor.
Graphical abstractA series of 2-piperazinyl-5-alkoxypyridines (3) were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the human GPR119 receptor.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yulin Wu, Judith D. Kuntz, Andrew J. Carpenter, Jing Fang, Howard R. Sauls, Daniel J. Gomez, Carina Ammala, Yun Xu, Shane Hart, Sarva Tadepalli,