| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375134 | Bioorganic & Medicinal Chemistry Letters | 2010 | 6 Pages |
Abstract
A novel series of tricyclic γ-secretase inhibitors was designed and synthesized via a conformational analysis of literature compounds. The preliminary results have shown that compounds in this new series have much improved in vitro potency and in vivo profiles. More importantly, they have greatly reduced Notch related toxicity that was associated with previous γ-secretase inhibitors.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ruo Xu, David Cole, Ted Asberom, Tom Bara, Chad Bennett, Duane A. Burnett, John Clader, Martin Domalski, William Greenlee, Lynn Hyde, Hubert Josien, Hongmei Li, Mark McBriar, Brian McKittrick, Andrew T. McPhail, Dmitri Pissarnitski, Li Qiang,