(−)-Carbodine: Enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu)

Enantiomerically pure cyclopentyl cytosine [(−)-carbodine 1] was synthesized from d-ribose and evaluated for its anti-influenza activity in vitro in comparison to the (+)-carbodine, (±)-carbodine and ribavirin. (−)-Carbodine 1 exhibited potent antiviral activity against various strains of influenza A and B viruses.

Graphical abstractEnantiomerically pure cyclopentyl cytosine [(−)-carbodine] exhibited potent antiviral activity against H5N1 (avian) and novel H1N1 (swine) flu.Figure optionsDownload full-size imageDownload as PowerPoint slide