| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375138 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
We have designed and synthesized a novel series of 2,8-diaryl-quinoxalines as Janus kinase 2 inhibitors. Many of the inhibitors show low nanomolar activity against JAK2 and potently suppress proliferation of SET-2 cells in vitro. In addition, compounds from this series have favorable rat pharmacokinetic properties suitable for in vivo efficacy evaluation.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Carole Pissot-Soldermann, Marc Gerspacher, Pascal Furet, Christoph Gaul, Philipp Holzer, Clive McCarthy, Thomas Radimerski, Catherine H. Regnier, Fabienne Baffert, Peter Drueckes, Gisele A. Tavares, Eric Vangrevelinghe, Francesca Blasco,