| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375169 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of novel benzoxazole benzenesulfonamides was synthesized as inhibitors of fructose-1,6-bisphosphatase (FBPase-1). Extensive SAR studies led to a potent inhibitor, 53, with an IC50 of 0.57 μM. Compound 17 exhibited excellent bioavailability and a good pharmacokinetic profile in rats.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chunqiu Lai, Rebecca J. Gum, Melissa Daly, Elizabeth H. Fry, Charles Hutchins, Celerino Abad-Zapatero, Thomas W. von Geldern,