| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375170 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
We have identified benzoxazole benzenesulfonamide 1 as a novel allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1). X-ray crystallographic and biological studies of 1 indicate a distinct binding mode that recapitulates features of several previously reported FBPase-1 inhibitor classes.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thomas W. von Geldern, Chunqiu Lai, Rebecca J. Gum, Melissa Daly, Chaohong Sun, Elizabeth H. Fry, Celerino Abad-Zapatero,