| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375178 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
6-Hydroxycinnolines 2 and cyclohexa-2,5-diene-1,4-dione derivatives 6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 6-Hydroxycinnolines 2 showed, in general, more potent antifungal activity against Candida species than the other cyclohexa-2,5-diene-1,4-diones. The results suggest that 6-hydroxycinnolines would be potent antifungal agents.
Graphical abstract6-Hydroxycinnolines and cyclohexa-2,5-diene-1,4-dione derivatives were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. Among them, 2-amino-7,8-dimethyl-6-hydroxycinnolines exhibited potent antifungal activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chung-Kyu Ryu, Jung Yoon Lee,