| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375184 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Constrained ceramide analogs were designed and synthesized by binding terminal alcohol and amine of ceramide with additional carbonyl functional group as 3-acetyl (3), 3-propionyl (4), 3-benzoyl (5), and 3-hexadecanoyl-4-(1-hydroxyhexadec-2-enyl)-oxazolidin-2-ones (6). Compounds 4 and 5 showed potent antileukemic activities against human leukemia HL-60 cells with good correlation between cell death and DNA fragmentation.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hyun-Joon Ha, Myeng Chan Hong, Seung Whan Ko, Yong Woo Kim, Won Koo Lee, Jungchan Park,