| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375189 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Miltirone analogues were synthesized and evaluated for inhibitory activity against Cdc25 and PTP1B. Most of the compounds demonstrated potent Cdc25 inhibitory activity, and several exhibited higher selectivity for Cdc25 than for PTP1B. In a cytotoxic assay, most of the compounds displayed cytotoxicity against the tumor cell lines A549 and HCT-116, producing IC50 values in the micromolar range.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Weigang Huang, Jingya Li, Wei Zhang, Yueyang Zhou, Chuanming Xie, Yu Luo, Yunfei Li, Jingli Wang, Jia Li, Wei Lu,