| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375190 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A novel ketone derivative of artemisinin, artemisitone-9, was produced by the biotransformation of cultured Streptomyces griseus ATCC 13273. The structure of the ketone product was fully elucidated by various spectroscopic techniques, and the mechanism of generating such novel metabolite is also discussed.
Graphical abstractArtemisinin (1) was regioselectively converted to artemisitone-9 (2) and three other oxidative metabolites by Streptomyces griseus ATCC 13273.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ji-Hua Liu, You-Gen Chen, Bo-Yang Yu, Yi-Jun Chen,