Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1375192 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The HIV pol gene encodes three viral enzymes that are required for its replication. While drug discovery involving the viral targets, reverse transcriptase and protease, has resulted in useful therapeutic agents, such efforts on HIV integrase have not produced a single FDA-approved drug. In the work focused on the discovery of inhibitors of HIV integrase, we have synthesized new β-diketo acids with purine nucleobase scaffolds that are potent inhibitors of the strand transfer steps of wild-type HIV-1 integrase.
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Related Topics
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Organic Chemistry
Authors
Vasu Nair, Vinod Uchil, Nouri Neamati,