| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375194 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A new series of erythromycin A derivatives, the 6-O-heteroarylcarbamoyl-11,12-lactoketolides, with activity against macrolide-resistant streptococci, are described. Structurally, these macrolide antibiotics are characterized by a heteroaryl side chain attached to the macrolactone core through a carbamate linkage at the C6 position, as well as 11,12-γ-lactone and 3-keto functionalities. The synthesis and antibacterial activity of this new series of ketolides are discussed.
Graphical abstractA short, concise synthesis of 6-O-carbamoyl-11,12-lactoketolide derivatives and their corresponding antibacterial activity are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Eugene B. Grant, Deodialsingh Guiadeen, Darren Abbanat, Barbara D. Foleno, Karen Bush, Mark J. Macielag,