| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375235 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Polycyclic amides 2 and 5–9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor subtypes demonstrated their P2X7 selectivity.
Graphical abstractCubyl amides were successfully synthesised. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hendra Gunosewoyo, Jun Liu Guo, Maxwell R. Bennett, Mark J. Coster, Michael Kassiou,