| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375241 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Several reference compounds such as Cyclosporin A, Tamoxifen, Verapamil, and our compound 1, known as P-gp modulators, have been tested for their P-gp modulating activity in isolated organ bath. Compound 1 showed the best result in organ bath experiment (EC50 = 14.7 μM), Cyclosporin A and Tamoxifen displayed EC50 = 25.2 and 39.4 μM, respectively.
Graphical abstractThe inhibition of Rhodamine-123 efflux in guinea-pig ileum by several P-gp inhibitors is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Nicola Antonio Colabufo, Francesco Berardi, Marialessandra Contino, Carmela Inglese, Mauro Niso, Roberto Perrone,