| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375245 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Various derivatives of reveromycin A, an inhibitor of eukaryotic cell growth, and spirofungin A, focusing on the 5S hydroxyl group and C18 hemisuccinyl group, were synthesized and their inhibitory effects on both the isoleucyl-tRNA synthetase activity and the survival of osteoclasts, and activities on the morphological reversion of srcts-NRK cells were examined. It was found that 2,3-dihydroreveromycin A is the promising derivative of reveromycin A based on the activity and stability.
Graphical abstractVarious derivatives of reveromycin A and spirofungin A were synthesized and their inhibitory effects on both the isoleucyl-tRNA synthetase activity and the survival of osteoclasts were examined.Figure optionsDownload full-size imageDownload as PowerPoint slide
