| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375275 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Herein we report the syntheses of 2,3-diaryl-substituted pyrrolo[3,2-b]pyridine-5-carbonitriles via a one-pot 5-endo-dig-cyclization/protection reaction followed by palladium catalyzed arylation. In addition, a complementary synthesis route employing Larock methodology is applied to efficiently explore further aryl moieties in the 2-position. The novel compounds’ expedient c-Met receptor tyrosine kinase inhibition activity is discussed.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hannes Koolman, Timo Heinrich, Henning Böttcher, Wilfried Rautenberg, Michael Reggelin,