| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375288 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
A series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure–activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells are presented. These compounds were found to have effects on T cell proliferation, however it is not clear whether the mechanism is related to PDE7 inhibition.
Graphical abstractA series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure–activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells are presented. These compounds were found to have effects on T cell proliferation, however it is not clear whether the mechanism is related to PDE7 inhibition.Figure optionsDownload full-size imageDownload as PowerPoint slide
