Semi-synthetic analogs of pinitol as potential inhibitors of TNF-α cytokine expression in human neutrophils

Semi-synthetic analogs of pinitol were subjected to screening by determining TNF-α expression in human neutrophils using flowcytometry. Among the tested compounds, three derivatives displayed more than 50% inhibition of TNF-α cytokine secretion in LPS induced stimulated neutrophils and can be considered as potent anti-inflammatory moieties.

Graphical abstractSemi-synthetic analogs of pinitol were prepared using chemo-enzymatic approaches and their TNF-α expression in human neutrophils using flowcytometry is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide