| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375307 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A simplified C32 monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-γ and IL-6 were produced in spleen cells from mice immunised with a C32 MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6′-di-behenate (TDB).
Graphical abstractA C32 monomycolyl glycerol analogue demonstrated elevated INF-γ and IL-6 levels, comparable to that of the potent Th1 adjuvant trehalose 6,6′ di-behenate (TBD) in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Veemal Bhowruth, David E. Minnikin, Else Marie Agger, Peter Andersen, Vincent W. Bramwell, Yvonne Perrie, Gurdyal S. Besra,