| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375315 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and evaluated. The most potent compound, compound 23, showed potent growth inhibitory activities on both prostate and breast cancer lines with IC50 values in sub-micromolar range, fifty times more potent than curcumin. Curcumin analogues might be potential anti-tumor agents for breast and prostate cancers.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
James R. Fuchs, Bulbul Pandit, Deepak Bhasin, Jonathan P. Etter, Nicholas Regan, Dalia Abdelhamid, Chenglong Li, Jiayuh Lin, Pui-Kai Li,