| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375330 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Synthesis of a number of bicyclic five-membered ring derivatives of gabapentin led to the identification of two compounds, (−)-(11A) and (20A) which both had an excellent level of potency against α2δ and were profiled in an in vivo model of neuropathic pain.
Graphical abstractA range of bicyclic gababutins were synthesised. Of these compounds (−)-(11A) and (20A) proved to have excellent levels of in vitro potency and were profiled in an in vivo model of neuropathic pain.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David C. Blakemore, Justin S. Bryans, Pauline Carnell, Christopher L. Carr, Nicola E.A. Chessum, Mark J. Field, Natasha Kinsella, Simon A. Osborne, Andrew N. Warren, Sophie C. Williams,