| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375339 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
The design and synthesis of novel opiates are reported. Based on the message-address principle a novel class of 4,4- and 3,3-biaryl piperidines was designed and synthesized. Biological evaluation confirmed that these compounds exhibit high affinity and selectivity for the delta opioid receptor. Key structure–activity relationships that influence affinity, selectivity, functional activity and clearance are reported.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Spiros Liras, Stanton F. McHardy, Martin P. Allen, Barb E. Segelstein, Steven D. Heck, Dianne K. Bryce, Anne W. Schmidt, Michelle Vanase-Frawley, Ernesto Callegari, Stafford McLean,