| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375343 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Replacement of a quinoline with an imidazo[1,2-a]pyridine in a series of liver X receptor (LXR) agonists incorporating a [3-(sulfonyl)aryloxyphenyl] side chain provided high affinity LXR ligands 7. In functional assays of LXR activity, good agonist potency and efficacy were found for several analogs.
Graphical abstractA series of 3-(3-aryloxyaryl)imidazo[1,2-a]pyridine sulfones 7 was prepared as LXR agonists.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists](/preview/png/1375343.png "First Page Preview: 3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists")
Authors
Robert R. Singhaus, Ronald C. Bernotas, Robert Steffan, Edward Matelan, Elaine Quinet, Ponnal Nambi, Irene Feingold, Christine Huselton, Anna Wilhelmsson, Annika Goos-Nilsson, Jay Wrobel,