| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1375345 | Bioorganic & Medicinal Chemistry Letters | 2010 | 6 Pages |
Abstract
An iterative analog library synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M1 positive allosteric modulators, and strategies for improving potency and plasma free fraction were identified.
Graphical abstractA parallel synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M1 positive allosteric modulators, identifying strategies for improving potency and plasma free fraction.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Chemistry
Organic Chemistry
Authors
Feng V. Yang, William D. Shipe, Jaime L. Bunda, M. Brad Nolt, David D. Wisnoski, Zhijian Zhao, James C. Barrow, William J. Ray, Lei Ma, Marion Wittmann, Matthew A. Seager, Kenneth A. Koeplinger, George D. Hartman, Craig W. Lindsley,