Article ID Journal Published Year Pages File Type
1375346 Bioorganic & Medicinal Chemistry Letters 2010 4 Pages PDF
Abstract

Several studies have revealed piperine and a few related compounds as potent inhibitors of monoamine oxidases without delineating the underlying mechanism. Using in silico modelling, we propose a structural basis of such activity by showing that these compounds can successfully dock into the inhibitor binding pockets of human monoamine oxidase isoforms with predicted affinities comparable to some known inhibitors. The results therefore suggest that piperine can be a promising lead for developing novel monoamine oxidase inhibitors.

Graphical abstractThe putative molecular interaction of piperine and related compounds with human monoamine oxidases is assessed using computational docking.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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